KMID : 0043320120350020201
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Archives of Pharmacal Research 2012 Volume.35 No. 2 p.201 ~ p.211
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Perspectives on mesenchymal stem cells: Tissue repair, immune modulation, and tumor homing
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Hong Hyun-Sook
Kim Yeong-Hoon Son Young-Sook
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Abstract
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Mesenchymal stem cells (MSCs) or MSC-like cells have been identified in a variety of different tissues that share molecular expression profiles and biological functions but also retain a unique differentiation preference depending on their tissue origins. MSCs play beneficial roles in the healing of damaged tissue by directly differentiating to many different resident cell types and/or by secreting several trophic factors that aid tissue repair. Aside from MSCs¡¯ reparative stem cell function, they drive immune responses toward immunosuppression and anti-inflammation. This novel function of MSCs opens up new avenues for clinical development of MSC immune-therapeutics to treat uncontrollable, life threatening, severe, chronic inflammation and autoimmune disease. Unexpectedly high rates of MSCs¡¯ tumor homing capacity and their tumor supporting capability have also been noted in tumor-bearing animal models. In this review, we will discuss MSCs¡¯ basic cell biology and perspectives on MSCs in terms of tissue repair, immune modulation, and tumor homing.
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KEYWORD
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MSC, Tissue repair, Immune modulation, Tumor homing, Adipose stem cell, Inflammation
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